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Sources
Phosphorus homeostasis try firmly regulated by the PTH/vitamin D/FGF-23 axis when you look at the people who have normal kidney form (come across Control). Enhanced hormonal out of PTH and you can FGF-23 helps keep phosphorus solution levels on the typical assortment (dos.5-4.5 mg/dL) inside the setting out-of higher phosphorus intake (9). That it results in gel phosphorus becoming just weakly coordinated in order to phosphorus use (22). Off note, suffered develops in FGF-23 and you may PTH are commonly noticed through the CKD to help you take care of normal solution phosphorus density despite a decrease in urinary phosphorus excretion (23). Raised FGF-23, in the place of serum phosphorus, is apparently a young marker of disordered phosphorus homeostasis and you can an effective predictor off unfavorable fitness consequences for the people that have early-stage CKD (23, 24). Therefore, it is practical to assume you to definitely computing solution phosphorus in the someone that have regular kidney setting you should never acceptably echo early interruptions in the phosphorus metabolic rate due to highest phosphorus application.
A combination-sectional analysis held in two,344 Brazilian individuals (median age, 58 years) shown an association anywhere between high phosphorus intakes and you can enhanced danger of crack. Yet, consumption off other nutritional supplements highly relevant to bones fitness, such as for example calcium supplements, magnesium, and you will nutritional D, was indeed underneath the RDA in this people, while phosphorus consumption was indeed near the RDA (35). Whilst it seems that hormones and you will calcium problems might be prevented from the an acceptable calcium-to-phosphorus consumption ratio, there is absolutely no persuading research the dieting phosphorus account knowledgeable in the us negatively affect limbs mineral density. However, this new replacement out-of phosphate-which includes soft drinks and snack foods having milk and other calcium-steeped dining could possibly get show a significant risk so you can limbs fitness (understand the overview of Calcium) (36).
17. Tonelli Yards, Sacks F, Pfeffer M, ainsi que al. Family anywhere between serum phosphate height and you can aerobic event speed within the somebody with heart problems. Flow. 2005;112(17):2627-2633. (PubMed)
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