Mathematical analyses
To look at contacts ranging from diet and heart attack, we put Cox proportional perils patterns stratified by the ages (mo) and you will realize-up years so you’re able to estimate RRs and you may 95% CIs. Players were divided into quintiles off cumulative average intake of magnesium, potassium, and you may calcium to reduce the inside-person type and greatest show a lot of time-term consumption ( 18). A mixed nutrient eating plan get out of magnesium, potassium, and calcium was calculated because of the assigning things to for every single quintile and you may summing the new items. Users on lower quintile (quintile step 1) away from magnesium, potassium, or calcium supplements consumption received step 1 point for each nutrient, participants in the next quintile (quintile dos) gotten dos factors, etc. Cumulative averages have been computed by using the new suggest of all the said FFQ intakes up to the start of for every single 2-y go after-right up interval. The fresh new cumulative average consumption was used so you can assume coronary arrest incidence out of committed of your own past returned survey before the second follow-up duration.
Multivariate activities was basically modified to have years (mo) and you will diary big date (2-y day periods) and you can integrated consumption out of complete time (kcal), alcoholic beverages (g/d), cigarette smoking, Bmi, physical exercise, adult reputation of very early myocardial infarction, postmenopausal hormones medication fool around with, thiazide play with, aspirin explore, multi vitamin play with, and you may reputation for diabetic issues, blood pressure levels, and you can hypercholesterolemia within baseline. To check on having a beneficial linear trend, i tasked each quintile brand new average worth and you can modeled which varying because the a continuing adjustable. I looked at the potential departure out of linearity that with a chances ratio try to own evaluation of a design into the linear name having an unit for instance the linear title and additionally restricted cubic spline changes ( 19). We along with presented analyses you to integrated the step 3 nutrients additionally. Magnesium and potassium intakes was basically extremely correlated (r = 0.79 throughout the NHS I; r = 0.73 about NHS II), and you may correlations anywhere between calcium and you can potassium intakes (r = 0.49 on the NHS I; roentgen = 0.41 on NHS II), whereas between calcium and you can magnesium intakes (roentgen = 0.54 from the NHS We; roentgen = 0.56 from the NHS II) had been modest. The Q test was utilized to evaluate towards the heterogeneity anywhere between the NHS I and you may NHS II. RRs (±SEs) each quintile out-of for every single cohort was basically pooled within the repaired-consequences https://datingranking.net/spiritual-dating-sites/ models in order to estimate conclusion estimates ( 20). Likewise, new up-to-date meta-investigation adopted standard behavior ( 20) of evaluation to possess heterogeneity utilizing the Q make sure playing with fixed outcomes model in order to make summary prices when zero anywhere between-training heterogeneity are clear; otherwise a haphazard-outcomes model was utilized.
To examine the potential effect modification of the association between dietary minerals and stroke risk by age, hypertension, and diabetes, we stratified our multivariate model on age (<60 compared with ?60 y), hypertension (yes compared with no), and diabetes (yes compared with no) and separately tested the significance of an interaction by using a likelihood ratio test for the comparison of the model with interaction terms to the model with only main effects. All P values were 2-sided, and analyses were conducted with SAS 9.2 software (SAS Institute Inc.).
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During 30 y of realize-upwards out-of 1980 using 2010 on NHS We and you may twenty-two y away from follow-up from 1989 as a consequence of 2011 regarding NHS II, a total of 3780 incident heart attack times have been determined. Of those circumstances, 3237 event shots have been recorded regarding NHS We (along with 1664 ischemic, 544 hemorrhagic, and 1029 unspecified shots), and you may 543 event shots was in fact reported from the NHS II (also 186 ischemic, ninety-five hemorrhagic, and you can 265 unspecified shots). Age-standard qualities regarding analysis participants in the midpoint through the go after-up inside 1994 with the NHS I plus 1995 having the NHS II are provided within the Table 1. Women that have higher mineral consumption have been more likely to explore aspirin, multivitamins, and you may postmenopausal hormones treatment, a whole lot more privately effective, less likely to want to be newest smokers than have been ladies having lower nutrient intake. Investigation for women about NHS We and you will NHS II had been mutual given that i failed to observe a significant ranging from-research heterogeneity (Q-fact P > 0.05).
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